BEYOND PHYSICAL EXHAUSTION: UNDERSTANDING OVERTRAINING SYNDROME THROUGH THE LENS OF MOLECULAR MECHANISMS AND CLINICAL MANIFESTATION

Beyond physical exhaustion: Understanding overtraining syndrome through the lens of molecular mechanisms and clinical manifestation

Background: Overtraining Syndrome (OTS) is a condition resulting from excessive physical activity without adequate recovery, predominantly affecting elite athletes and military personnel.While overreaching can be a temporary state, non-functional overreaching may progress to chronic OTS.This review explores various hypotheses regarding the pathogen

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Simulations and observation of nonlinear internal waves on the continental shelf: Korteweg–de Vries and extended Korteweg–de Vries solutions

Numerical solutions of the Korteweg–de Vries (KdV) and extended Korteweg–de Vries (eKdV) Probiotics for Adults equations are used to model the transformation of a sinusoidal internal tide as it propagates across the continental shelf.The ocean is idealized as being a two-layer fluid, justified by the fact that most of the oceanic intern

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ACTIVITIES OF THE LOCAL ADMINISTRATIVE COMMITTEES OF THE TOMSK PROVINCE IN METAYAGE DISTRIBUTION IN THE EARLY XX CENTURY

The article is devoted to the activities of the county administrative committees for the distribution of metayage among the local population.By using earlytwentieth-century archival materials concerning the Tomsk province, the author was able to draw the conclusion that institutions under consideration applied a considerable effort Microwave Turnta

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Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration

Disulfiram has been used in the treatment of alcoholism and exhibits an Holdalls anti-tumor effect.However, the intracellular mechanism of anti-tumor activity of Disulfiram remains unclear.In this study, we focused on the modulatory role of Disulfiram via oncogenic factor carbonic anhydrase CA12 and its associated transporter anion exchanger AE2 in

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